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Ugeskrift for laeger · Jun 2005
Randomized Controlled Trial Comparative Study Clinical Trial[Effect of the synthetic cannabinoid dronabinol on central pain in patients with multiple sclerosis--secondary publication].
- Kristina Bacher Svendsen, Troels Staehelin Jensen, and Flemming W Bach.
- Dansk Smerteforskningscenter, Neurologisk Afdeling F, Arhus Universitetshospital, Arhus Sygehus. kristina@akhphd.au.dk
- Ugeskr. Laeg. 2005 Jun 20;167(25-31):2772-4.
AbstractCannabinoids reduce allodynia/hyperalgesia in animal pain models, but few clinical studies evaluated the analgesic action in humans. We aimed to evaluate the effect of delta-9-tetrahydrocannabinol (dronabinol) on central pain in MS patients. Twenty-four MS patients participated in a double-blind placebo-controlled crossover trial. Dronabinol reduced the spontaneous pain intensity significantly compared with placebo (4.0 (2.3-6.0) vs. 5.0 (4.0-6.4), median (25th-75th percentiles), p = 0.02). Though dronabinol's analgesic effect is modest, its use should be evaluated considering the general difficulty in treating central pain.
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