• Praxis · Mar 1999

    Case Reports

    [Methotrexate pneumonitis].

    • K Zingg, M Grossenbacher, D Conen, and K Truninger.
    • Medizinische Klinik, Kantonsspital Aarau.
    • Praxis (Bern 1994). 1999 Mar 25;88(13):573-8.

    AbstractA 72 year old female with rheumatoid arthritis was treated with methotrexate for nine months. Four days before admission she complained of dyspnea NYHA III. Chest-X-ray revealed diffuse interstitial pneumopathy. Pulmonary infection was excluded by several microbiological samples. A pulmonary manifestation of rheumatoid arthritis is usually more chronic. Methotrexate-induced pneumonitis remained the most probable diagnosis. We halted methotrexate and initiated therapy with glucocorticoids. This treatment led to rapid clinical improvement and complete resolution of radiological changes.

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