• Clinics in liver disease · May 2008

    Review

    Fatigue in primary biliary cirrhosis.

    • Julia L Newton.
    • Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle, United Kingdom, NE2 4HH. Julia.newton@nuth.nhs.uk <Julia.newton@nuth.nhs.uk>
    • Clin Liver Dis. 2008 May 1;12(2):367-83; ix.

    AbstractThe autoimmune liver disease, primary biliary cirrhosis (PBC), is associated with debilitating fatigue in a significant proportion of patients. The pathogenesis of fatigue in PBC is unclear, but preliminary studies suggest it has central mechanisms and may have peripheral manifestations. Studies are beginning to elucidate the biological associates of fatigue in PBC, particularly sleep disturbance and autonomic dysfunction. Comprehensive studies investigating the pathogenesis of fatigue in PBC are urgently needed as are large-scale prospective outcome studies.

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