• Jean-Louis Vincent, Sameer Jog, Linda Schmitz, Shirish Prayag, Sunitha Varghese, Pallavi Bhargav-Patil, and Deepak Salunke.
• Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, Belgium.
• J Crit Care. 2011 Oct 1;26(5):441-8.

PurposeThe purpose of the study was to explore determinants of outcome in adults with dengue hemorrhagic fever or dengue shock syndrome.MethodsWe performed a multicenter, retrospective, observational study over a 2-year period in 3 intensive care units (ICUs) in Pune (India).ResultsOne hundred eighty-four adult patients were admitted to the ICU with a positive dengue immunoglobulin M test result; 43 met the World Health Organization criteria for dengue hemorrhagic fever or dengue shock syndrome. One patient who was transferred to another hospital and whose outcome was unknown was not included in the analysis. Of the 42 patients, 20 (48%) had multiorgan failure on ICU admission. The ICU mortality was 19% (8/42). Nonsurvivors were more likely than survivors to have cardiovascular (100% vs 12%), respiratory (88% vs 12%), or neurological (75% vs 12%) failure (all P < .01). Hematological failure was not associated with a higher risk of death. Cumulative fluid balance at 72 hours was more positive in nonsurvivors than in survivors (6.2 vs 3.5 L, P < .05). Serum albumin concentrations at ICU admission were lower in nonsurvivors than in survivors (2.9 ± 0.3 vs 3.4 ± 0.7 g/dL, P < .05).ConclusionsIn our cohort, outcome from severe dengue was primarily related to nonhematological organ failure. Low serum albumin concentration on ICU admission and a more positive fluid balance at 72 hours were also associated with worse outcomes.Copyright © 2011 Elsevier Inc. All rights reserved.

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