• Zhonghua yi xue za zhi · Sep 2013

    Randomized Controlled Trial

    [Effect analysis of multimode analgesia of parecoxib sodium during laparoscopic cholecystectomy].

    • Ren-bing Bi, Ling Ji, and Xiao-kun Wang.
    • Third Department of General Surgery, First Municipal People's Hospital, Jingmen 448000, China.
    • Zhonghua Yi Xue Za Zhi. 2013 Sep 10;93(34):2727-9.

    ObjectiveTo explore the effects of parecoxib sodium multimode analgesia on postoperative analgesia in patients undergoing laparoscopic cholecystectomy (LC).MethodsA prospective, double-blind, randomized and placebo-controlled study was conducted on 80 patients undergoing elective LC at Department of Endoscopic Surgery, First Affiliated Hospital, Wenzhou Medical College from March 2011 to June 2011. They were randomized to receive either 40 mg parecoxib infusion 30 min preoperative and at 12, 24, 36, 48 h post-operation (treatment group). And 2 ml normal saline infusion was administered similarly as a placebo (control group). All patients received ropivacaine infusion at port sites at the end of LC. The degree of postoperative pain was assessed with visual analog scale (VAS) at 1, 2, 4, 8, 12, 24, 36, 48 h post-operation respectively. The consumption of pethidine in the first 24 h post-operation was also recorded.ResultsThe VAS pain scores at each timepoint were significantly lower in the treatment group than those in the control group (1 h: 1.0 ± 0.6 vs 1.8 ± 0.6, t = -1.650, P = 0.000;2 h: 1.3 ± 0.6 vs 1.9 ± 0.7, t = -4.302, P = 0.000; 4 h: 1.6 ± 0.7 vs 2.7 ± 1.2, t = -4.752, P = 0.000;8 h: 2.5 ± 1.4 vs 5.0 ± 1.8, t = -6.835, P = 0.000; 12 h: 2.2 ± 1.1 vs 3.3 ± 1.5, t = -3.902, P = 0.000; 24 h: 1.6 ± 0.8 vs 2.5 ± 1.4, t = -3.649, P = 0.000; 36 h: 1.2 ± 0.6 vs 2.2 ± 0.8, t = -6.390, P = 0.000; 48 h: 1.0 ± 0.5 vs 1.5 ± 0.6, t = -3.710, P = 0.000). And the amount of pethidine used in the first 24h after LC was also less in the treatment group (150 vs 950 mg, χ(2) = 16.200, P = 0.000).ConclusionThe infusion multimode analgesia of parecoxib sodium 40 mg provides significant effect of postoperative pain relief after laparoscopic cholecystectomy.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…