• Br J Anaesth · Sep 1992

    Randomized Controlled Trial Comparative Study Clinical Trial

    Pain on injection of propofol: comparison of lignocaine with metoclopramide.

    • R Ganta and J P Fee.
    • Department of Anesthesiology, University of Oklahoma 73190.
    • Br J Anaesth. 1992 Sep 1;69(3):316-7.

    AbstractWe have conducted a randomized, double-blind study in 255 ASA I and II patients to compare the efficacy of lignocaine and metoclopramide in minimizing the pain of injection of i.v. propofol. When administered immediately before propofol into a dorsal hand vein, compared with placebo both drugs significantly reduced the incidence of pain on subsequent injection of propofol (P < 0.001). Twenty patients who had received metoclopramide (n = 85) experienced pain, compared with 18 who had received lignocaine (n = 85) and 42 who had been pretreated with saline (n = 85).

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