• Jacob Alexander, Prathap Tharyan, Clive Adams, Thomas John, Carina Mol, and Joncy Philip.
• Department of Psychiatry, Christian Medical College, Vellore, Tamil Nadu, India. dralexander_in@yahoo.com
• Br J Psychiatry. 2004 Jul 1;185:63-9.

BackgroundThe pharmacological management of violence in people with psychiatric disorders is under-researched.AimsTo compare interventions commonly used for controlling agitation or violence in people with serious psychiatric disorders.MethodWe randomised 200 people to receive intramuscular lorazepam (4 mg) or intramuscular haloperidol (10 mg) plus promethazine (25-50 mg mix).ResultsAt blinded assessments 4 h later (99.5% follow-up), equal numbers in both groups (96%) were tranquil or asleep. However, 76% given the haloperidol-promethazine mix were asleep compared with 45% of those allocated lorazepam (RR=2.29,95% CI 1.59-3.39; NNT=3.2,95% CI 2.3-5.4). The haloperidol-promethazine mix produced a faster onset of tranquillisation/sedation and more clinical improvement over the first 2 h. Neither intervention differed significantly in the need for additional intervention or physical restraints, numbers absconding, or adverse effects.ConclusionsBoth interventions are effective for controlling violent/agitated behaviour. If speed of sedation is required, the haloperidol-promethazine combination has advantages over lorazepam.

27 keywords...

hide…