• Masui · Jan 2006

    Comparative Study Clinical Trial

    [Preoperative sedation with dexmedetomidine in patients with aneurysmal subarachnoid hemorrhage].

    • Kiyotaka Sato, Hideyuki Kamii, Hiroaki Shimizu, and Masato Kato.
    • Department of Neuroanesthesia, Kohnan Hospital, Sendai 982-8523.
    • Masui. 2006 Jan 1;55(1):51-4.

    BackgroundDexmedetomidine could be beneficial for preoperative sedation of patients with aneurysmal subarachnoid hemorrhage (SAH) because of its sympathetic suppressive effect without respiratory depression.MethodsThirteen patients were sedated with continuous intravenous administration of dexmedetomidine (group D) and 13 were with intermittent intravenous administration of diazepam and pentazocine (group C).ResultsBlood pressure (BP) and heart rate (HR) on admission to OR in group D were lower than those in group C. On tracheal intubation, BP and HR increased in both groups, but the differences between the values before and after the intubation were larger in group C than in D.ConclusionsPreoperative dexmedetomidine infusion is suitable for patients with SAH.

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