• Vasc Endovascular Surg · Oct 2010

    Randomized Controlled Trial Comparative Study

    Vascular surgical antibiotic prophylaxis study (VSAPS).

    • Stone Patrick, Campbell James, Aburahma Ali, Safley Lawson, Emmett Mary, and Asmita Modak.
    • Charleston Division, Vascular Surgery, West Virginia University, WV, USA. pstone0627@yahoo.com
    • Vasc Endovascular Surg. 2010 Oct 1;44(7):521-8.

    AbstractThis prospective, randomized study was performed at a single institution. Low-risk patients undergoing elective vascular procedures were enrolled (August 2007 to June 2009). Participants were randomized into 3 separate arms. They received cefazolin, cefazolin + vancomycin, or cefazolin + daptomycin prior to surgery. In total, 169 patients were included in the analysis. Mean age was 64 (range, 26-85), and the patients' comorbidities were similar across all groups. Only Szilagyi II and III infections were analyzed. Any infection/methicillin-resistant Staphylococcus aureus (MRSA) infections was seen in 8 (12.9%)/2 (3.23%) in the cefazolin group, 7 (12.5%)/4 (7.14%) in the cefazolin + vancomycin group, and 2 (3.92%)/(0%) in the cefazolin + daptomycin group. In this study, population of low-risk patients undergoing elective vascular procedures, there was a trend toward fewer infectious complications in the cefazolin + daptomycin group. Adding anti-MRSA agents to the current standard prophylaxis regimen does not appear to reduce the incidence of MRSA infection in low-risk patients.

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