• Jeffrey J Bruno, Brian M Dee, Brent A Anderegg, Mike Hernandez, and S Egbert Pravinkumar.
• Division of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030-4009, USA. jjbruno@mdanderson.org
• J Crit Care. 2012 Aug 1;27(4):351-61.

PurposeThe aim of this study was to examine opinions and practices of US critical care practitioners (USCCPs) toward corticosteroid therapy in adult patients with severe sepsis or septic shock.Materials And MethodsA multicenter, electronic survey of USCCP members of the Society of Critical Care Medicine was conducted between March 18 and July 31, 2009.ResultsA total of 542 USCCPs responded to the survey. The majority (83%) do not commonly use corticosteroids in adult patients with severe sepsis; however, up to 81% report use of corticosteroids for septic shock. Twenty-eight percent believe that corticosteroids reduce mortality in septic shock, whereas 27% do not and 45% are unsure. The decision to initiate therapy is based, more often, on a patient's clinical status (65%) vs serum cortisol analysis (35%). Hydrocortisone is the most common corticosteroid prescribed (93%), with a median dosage of 200 mg/d and administration via intermittent intravenous injection. The Corticosteroid Therapy of Septic Shock trial had a large impact on survey respondents, with 62% reporting a practice change. Among the 19% of practitioners who do not prescribe corticosteroids, the most common reason was lack of proven survival benefit.ConclusionsCorticosteroids are commonly used by USCCPs in adult patients with septic shock; however, criteria used to initiate therapy and opinions regarding their impact vary.Copyright © 2012 Elsevier Inc. All rights reserved.

19 keywords...

hide…