• Dermatology (Basel) · Jan 1997

    Comparative Study

    The influence of long-term treatment with povidone-iodine on thyroid function.

    • K Nobukuni, N Hayakawa, R Namba, Y Ihara, K Sato, H Takada, T Hayabara, and S Kawahara.
    • Department of Neurology, National Sanatorium Minami-Okayama Hospital, Japan.
    • Dermatology (Basel). 1997 Jan 1;195 Suppl 2:69-72.

    AbstractPovidone-iodine (PVP-I) is generally very safe, but cases of thyroid dysfunction induced by PVP-I have been reported. The effect of long-term treatment with PVP-I on thyroid function was to be assessed. In 40 inpatients of the department of neurology, the status of the use of PVP-I preparations and their effects on serum inorganic iodine levels and thyroid functions were investigated. In 27 patients treated with PVP-I for a long term, inorganic iodine levels were significantly increased as compared to those in 13 patients without PVP-I treatment. Out of 27 patients treated with PVP-I in the long term, subclinical hypothroidism was seen in 3 patients, mild hyperthroidism was seen in 1 patient, and subclinical hyperthyroidism was suspected in 7 patients. Patients treated with PVP-I for a long time should be observed carefully for any manifestation of thyroid dysfunction.

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