• FEMS Immunol. Med. Microbiol. · Feb 2010

    Differences between tuberculosis cases infected with Mycobacterium africanum, West African type 2, relative to Euro-American Mycobacterium tuberculosis: an update.

    • Bouke C de Jong, Ifedayo Adetifa, Brigitte Walther, Philip C Hill, Martin Antonio, Martin Ota, and Richard A Adegbola.
    • Bacterial Diseases Programme, MRC Laboratories, Banjul, The Gambia. bdejong@mrc.gm
    • FEMS Immunol. Med. Microbiol. 2010 Feb 1;58(1):102-5.

    AbstractMycobacterium africanum (MAF) is a common cause of human pulmonary tuberculosis in West Africa. We previously described phenotypic differences between MAF and Mycobacterium tuberculosis (MTB) among 290 patients. In the present analysis, we compared 692 tuberculosis patients infected with the two most common lineages within the (MTB) complex found in the Gambia, namely MAF West African type 2 (39% prevalence) and Euro-American MTB (55% prevalence). We identified additional phenotypic differences between infections with these two organisms. MAF patients were more likely to be older and HIV infected. In addition, they had worse disease on chest X-ray, despite complaining of cough for an equal duration, and were more likely severely malnourished. In this cohort, the prevalence of MAF did not change significantly over a 7-year period.

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