• Curr Cardiol Rep · Mar 2001

    Review Comparative Study

    Are all beta-blockers the same for chronic heart failure?

    • S S Gottlieb.
    • Division of Cardiology, University of Maryland Medical Systems, 22 South Greene Street, Baltimore, MD 21201, USA. sgottlie@medicine.umaryland.edu
    • Curr Cardiol Rep. 2001 Mar 1;3(2):124-9.

    Abstractbeta-Adrenergic receptor blockade has been conclusively proven to increase survival and morbidity in patients with heart failure. Hospitalization rate decreases and patients feel better after receiving beta-blockers. Furthermore, this benefit is observed in a wide range of patients. The beta-blockers bisoprolol, metoprolol, and carvedilol have been extensively evaluated in heart failure patients. These drugs all show marked benefit. Bucindolol, an investigational beta-blocker, showed only mild improvement in survival in patients with heart failure. The beta-blockers differ regarding beta-selectivity, vasodilation properties, and perhaps other ancillary properties. At present, the importance and consequences of these differences are unknown.

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