• Magnes Res · Dec 2011

    Randomized Controlled Trial

    Analysis of the effect of perioperative magnesium sulphate on minimal alveolar concentration of desflurane using bispectral index monitoring.

    • Yakup Tomak, Murat Tekin, Ismail Kati, Ceyda Belenli, and Meltem Aydogmus.
    • Department of Anesthesiology, Faculty of Medicine, Rize University, Rize, Turkey. tomakyakup@hotmail.com
    • Magnes Res. 2011 Dec 1;24(4):181-8.

    BackgroundIn this study we aimed to analyze the effect of perioperative magnesium sulphate (MgSO(4)) on minimal alveolar concentration (MAC) of desflurane using bispectral index (BIS) monitoring.Patients And MethodsSixty patients undergoing abdominal surgery under general anesthesia were randomized into two groups: Mg - receiving perioperative MgSO(4) supplementation and C - control. Anesthesia was titrated to maintain the BIS value between 45-55.ResultsMAC values, tachycardia and hypertension during intubation was found to be lower in group Mg compared to group C (p<0.001). Time to extubation, verbal cooperation and eye opening was longer in patients receiving infusion of MgSO(4) (p<0.001).ConclusionWe concluded that perioperative MgSO(4) infusion may be used as an adjunct as it decreases MAC of desflurane and suppresses the hemodynamic response to intubation.

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