• Sichuan Da Xue Xue Bao Yi Xue Ban · May 2009

    Randomized Controlled Trial

    [Effects of granisetron/lidocaine combination on propofol injection-induced pain: a double-blind randomized clinical trial].

    • Yu-shan Ma, Xue-mei Lin, and Jun Zhou.
    • Department of Anesthesiology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
    • Sichuan Da Xue Xue Bao Yi Xue Ban. 2009 May 1;40(3):536-8.

    ObjectiveTo investigate the alleviation effect of vein pretreatment and granisetron/lidocaine combination on propofol injection-induced pain.MethodsTwo hundreds patients scheduled for gynaecological laparoscopic operations were randomly divided into four groups: control group (group I), lidocaine group (group II), granisetron group (group III) and granisetron/lidocaine combination group (group IV), with 50 patients in each group. The patients in the above four groups received placebo (saline), lidocaine 20 mg, granisetron 2 mg and granisetron 2 mg plus lidocaine intravenously respectively. The patients were injected with one-forth of scheduled propofol via a dorsal hand vein after one minute of venous occlusion. The pain during the injection of propofol was evaluated.ResultsPain occurred in 84% of patients in the control group, 46% in the lidocaine group, 52% in the granisetron group and 24% in the granisetron/lidocaine combination group. There was a significant reduction in pain incidence in the three experimental groups compared with the control group (P<0.05). The incidence of pain, nausea, vomiting and shivering was less in the granisetron/lidocaine combination group than in the control group (P<0.05).ConclusionPretreatment with granisetron/lidocaine may be effective not only in attenuating pains during i.v. injection of propofol, but also in preventing postoperative nausea, vomiting and shivering.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…