• Prog. Neuropsychopharmacol. Biol. Psychiatry · Apr 2014

    Comparative Study

    Minocycline improves recognition memory and attenuates microglial activation in Gunn rat: a possible hyperbilirubinemia-induced animal model of schizophrenia.

    • Kristian Liaury, Tsuyoshi Miyaoka, Toshiko Tsumori, Motohide Furuya, Sadayuki Hashioka, Rei Wake, Keiko Tsuchie, Michiyo Fukushima, Erlyn Limoa, Andi Jayalangkara Tanra, and Jun Horiguchi.
    • Department of Psychiatry, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo 693-8501, Japan; Department of Psychiatry, Hasanuddin University Faculty of Medicine, Jl. Perintis Kemerdekaan Km. 10, Makassar 90245, South Sulawesi, Indonesia. Electronic address: krizbox@hotmail.com.
    • Prog. Neuropsychopharmacol. Biol. Psychiatry. 2014 Apr 3;50:184-90.

    BackgroundAccumulating evidence indicates that neuroinflammation plays a significant role in the pathophysiology of schizophrenia. We previously reported evidence of schizophrenia-like behaviors and microglial activation in Gunn rats. We concluded that the Gunn rat, which exhibits a high concentration of unconjugated bilirubin, may be useful as an animal model of schizophrenia. On the other hand, there have been numerous reports that minocycline is effective in treating schizophrenia.MethodsIn the present study, we investigated the effects of minocycline on performance of behavioral tests (prepulse inhibition (PPI) and novel object recognition test (NORT)) after animals received either 40mg/kg/d of minocycline or vehicle by intraperitoneal (i.p.) injection for 14 consecutive days. Furthermore, we examined the effects of minocycline on microglial activation in the hippocampal dentate gyrus of Gunn rats and Wistar rats.ResultsWe found that administration of minocycline for 14days significantly increased the exploratory preference in retention sessions and tended to improve the PPI deficits in Gunn rats. Immunohistochemistry analysis revealed that microglial cells in the minocycline-treated Gunn rat group showed less expression of CD11b compared to vehicle-treated Gunn and Wistar groups.ConclusionsOur findings suggest that minocycline improves recognition memory and attenuates microglial activation in the hippocampal dentate gyrus of Gunn rats. Therefore, minocycline may be a potential therapeutic drug for schizophrenia.Copyright © 2013. Published by Elsevier Inc.

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