• Fa yi xue za zhi · Jun 2009

    Review

    [Advances in research of ketamine addiction mechanism].

    • Wei-Li Liu, Shi-Zhong Bian, Zhen-Lun Gu, Xiao-Gang Jiang, and Zheng-Hong Qin.
    • Department of Forensic Medicine, Medical College of Soochow University, Suzhou 215123, China. liuweilisuda@sohu.com
    • Fa Yi Xue Za Zhi. 2009 Jun 1;25(3):200-3, 207.

    AbstractKetamine is a phencyclidine derivative acting primarily as a noncompetitive antagonist of N-methyl-D-aspartate (NMDA) excitatory glutamate receptors. As a common intravenous anaesthetic in clinic, it is also increasingly abused because of its hallucination and addiction effects. Based on the pharmacological and toxicologic characteristics of ketamine and the acknowledged addiction mechanism of other abused drugs, this article reviews the possible addiction mechanism of the ketamine in the aspects of its enhanced effects and reward systems, the anatomic structures, the related receptors and the individual differences.

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