• Br J Anaesth · Oct 1990

    Randomized Controlled Trial Comparative Study Clinical Trial

    Effects of alfentanil and fentanyl on induction of anaesthesia in patients with severe pregnancy-induced hypertension.

    • C C Rout and D A Rocke.
    • Department of Anaesthetics, University of Natal, Durban, South Africa.
    • Br J Anaesth. 1990 Oct 1;65(4):468-74.

    AbstractForty patients with severe pregnancy-induced hypertension presenting for Caesarean section under general anaesthesia were allocated randomly to receive either fentanyl 2.5 micrograms kg-1 or alfentanil 10 micrograms kg-1 as part of the anaesthetic induction sequence. In all patients, the cardiovascular response to tracheal intubation was measured. Both drugs attenuated the response equally but did not abolish it in all patients. Alfentanil 10 micrograms kg-1 is a suitable alternative to fentanyl 2.5 micrograms kg-1 for patients with pregnancy-induced hypertension.

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