• Handb Clin Neurol · Jan 2013

    Review

    Multiple system atrophy.

    • Gregor K Wenning and Florian Krismer.
    • Division of Clinical Neurobiology, Department of Neurology, Medical University, Innsbruck, Austria. Electronic address: gregor.wenning@i-med.ac.at.
    • Handb Clin Neurol. 2013 Jan 1;117:229-41.

    AbstractMultiple system atrophy (MSA) is a sporadic and fatal α-synuclein-linked oligodendrogliopathy manifesting with progressive autonomic failure, poorly levodopa-responsive parkinsonism, and cerebellar ataxia, in any combination. Here we review key aspects of MSA integrating important insights from rapidly emerging fields such as genetics, diagnostic work-up including imaging, and translational therapies aimed at disease modification.© 2013 Elsevier B.V. All rights reserved.

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