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Di Yi Jun Yi Da Xue Xue Bao · Nov 2004
Randomized Controlled Trial Clinical Trial[Effects of fentanyl on EC50 of ropivacaine for postoperative epidural analgesia after gynecological surgery].
- Jian-she Xu, Ji-wu Yang, Miao-ning Gu, and Ye-ming Chen.
- Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. mzkgmn@263.net
- Di Yi Jun Yi Da Xue Xue Bao. 2004 Nov 1;24(11):1326-7.
ObjectiveTo determine the effect of fentanyl on 50% effective concentration (EC50) of ropivacaine for postoperative epidural analgesia following gynecological surgery.MethodsSixty-five patients (ASA class I to II) scheduled for elective gynecological surgery were randomly divided into two groups to receive 20 ml ropivacaine (group R, n=33) or ropivacaine combined fentanyl (group RF, n=32) for postoperative epidural analgesia. The concentration of ropivacaine was adjusted according to double-blinded up-down sequential allocation. The efficacy was assessed using visual analog scores (VAS) and EC50 calculated using method of Dixon.ResultsThe EC50 of ropivacaine was 0.098% in group R and 0.069% in group RF, showing significant difference (P<0.01).ConclusionEC50 of ropivacaine for postoperative epidural analgesia determined by up-down sequential allocation is 0.098%, which can be decreased by the use of fentanyl.
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