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- Anne M Curtis, Jay Edelberg, Rebecca Jonas, Wade T Rogers, Jonni S Moore, Wajihuddin Syed, and Emile R Mohler.
- Trinity Biomedical Science Institute (TBSI), Dublin, Ireland. acurtis@tcd.ie
- Vasc Med. 2013 Aug 1;18(4):204-14.
AbstractEndothelial microparticles (EMPs) belong to a family of extracellular vesicles that are dynamic, mobile, biological effectors capable of mediating vascular physiology and function. The release of EMPs can impart autocrine and paracrine effects on target cells through surface interaction, cellular fusion, and, possibly, the delivery of intra-vesicular cargo. A greater understanding of the formation, composition, and function of EMPs will broaden our understanding of endothelial communication and may expose new pathways amenable for therapeutic manipulation.
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