• M Fasshauer, A A Joseph, J T Kowallick, C Unterberg-Buchwald, K D Merboldt, D Voit, M Steinmetz, W Staab, S Schaetz, S Zhang, J Frahm, J Lotz, and J M Sohns.
• Institute for Diagnostic and Interventional Radiology, Heart Centre, University Medical Centre, Georg-August-University Göttingen, Germany; DZHK, German Centre for Cardiovascular Research, Göttingen, Germany.
• Clin Radiol. 2014 Oct 1;69(10):1066-71.

AimTo evaluate the potential of real-time phase-contrast flow magnetic resonance imaging (MRI) at 40 ms resolution for the simultaneous determination of blood flow in the ascending aorta (AA) and superior vena cava (SVC) in response to reduced intrathoracic pressure (Mueller manoeuvre).Materials And MethodsThrough-plane flow was assessed in 20 healthy young subjects using real-time phase-contrast MRI based on highly undersampled radial fast low-angle shot (FLASH) with image reconstruction by regularized non-linear inversion. Haemodynamic alterations (three repetitions per subject = 60 events) were evaluated during normal breathing (10 s), inhalation with nearly closed epiglottis (10 s), and recovery (20 s).ResultsRelative to normal breathing and despite interindividual differences, reduced intrathoracic pressure by at least 30 mmHg significantly decreased the initial peak mean velocity (averaged across the lumen) in the AA by -24 ± 9% and increased the velocity in the SVC by +28 ± 25% (p < 0.0001, n = 23 successful events). Respective changes in flow volume per heartbeat were -25 ± 9% in the AA and +49 ± 44% in the SVC (p < 0.0001, n = 23). Flow parameters returned to baseline during sustained pressure reduction, while the heart rate was elevated by 10% (p < 0.0001) after the start (n = 24) and end (n = 17) of the manoeuvre.ConclusionsReal-time flow MRI during low intrathoracic pressure non-invasively revealed quantitative haemodynamic adjustments in both the AA and SVC.Copyright © 2014 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

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