• Chest · Jan 2004

    Randomized Controlled Trial Clinical Trial

    The efficacy of premixed nitrous oxide and oxygen for fiberoptic bronchoscopy in pediatric patients: a randomized, double-blind, controlled study.

    • Brigitte Fauroux, Peter Onody, Olivier Gall, Barbara Tourniaire, Serge Koscielny, and Annick Clément.
    • Service de Pneumologie Pédiatrique et INSERM 213, Hôpital d'Enfants Armand Trousseau, Paris, France. brigitte.fauroux@trs.ap-hop-paris.fr
    • Chest. 2004 Jan 1;125(1):315-21.

    Study Objectives: The aim of the study was to evaluate the efficacy and safety of premixed 50% nitrous oxide and oxygen on the quality of sedation and pain control during fiberoptic bronchoscopy (FB) in children.DesignA prospective, randomized, double-blind study.SettingPediatric pulmonary department in a pediatric tertiary university hospital.PatientsOne hundred five children aged 1 month to 18 years.InterventionsPatients inhaled after sedation and local anesthesia either premixed 50% nitrous oxide and oxygen (nitrous oxide group) or premixed 50% nitrogen and oxygen (control group) during FB.Measurement And ResultsThe rate of failure was significantly greater in the control group (62%) than in the nitrous oxide group (21%, p = 0.00003). The efficacy of premixed 50% nitrous oxide and oxygen was also demonstrated with higher satisfaction scores (p = 0.000001), lower Children's Hospital of Eastern Ontario Pain Scores (p = 0.002), better visual analog scale ratings (p = 0.03), and improved behavior scores. Side effects were minor and similar in both groups.ConclusionsThis study demonstrates the improved efficacy of sedation, pain control, and safety of premixed 50% nitrous oxide and oxygen for FB in children.

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