• Erica P A Rutten, Peter M A Calverley, Richard Casaburi, Alvar Agusti, Per Bakke, Bartolome Celli, Harvey O Coxson, Courtney Crim, David A Lomas, William Macnee, Bruce E Miller, Stephan I Rennard, Paul D Scanlon, Edwin K Silverman, Ruth Tal-Singer, Jørgen Vestbo, Michael L Watkins, and Emiel F M Wouters.
• Center of Expertise for Chronic Organ Failure (Ciro+), Horn, The Netherlands.
• Ann. Nutr. Metab. 2013 Jan 1;63(3):239-47.

AimsThe follow-up of the ECLIPSE study, a prospective longitudinal study to identify and define parameters that predict disease progression over 3 years in chronic obstructive pulmonary disease (COPD), allows the examination of the effect of body composition changes on COPD-related outcomes.MethodsBody composition and health status were established in 2,115 COPD patients, 327 smoking and 239 nonsmoking controls at baseline and 3 years, while mortality was recorded in year 2 and 3 in the COPD patients. Associations between fat free mass index (FFMI) and fat mass index (FMI) changes to deterioration in health status and mortality were determined.ResultsChange in FFMI and FMI over 3 years was small and comparable between the groups. Underweight and obese patients had the worst health status. Worsening health status was associated with FFMI decrease in underweight patients and FMI increase in overweight/obese patients. While overweight patients had the lowest mortality, FFMI or FMI decrease was associated with a higher mortality.ConclusionChanges in body composition over 3 years were small and comparable in COPD patients and control subjects. Nevertheless, muscle mass decline in underweight and fat mass increase in overweight/obese patients is associated with worsening health status. Overweight is associated with decreased mortality, but muscle mass and fat mass decline are detrimental for mortality.

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