• Kennon J Heard, Mary Ann Peberdy, Michael R Sayre, Arthur Sanders, Romergryko G Geocadin, Simon R Dixon, Todd M Larabee, Katherine Hiller, Albert Fiorello, Norman A Paradis, and Brian J O'Neil.
• University of Colorado Denver School of Medicine and the Colorado Emergency Medicine Research Center, Denver, CO, United States. kennon.heard@ucdenver.edu
• Resuscitation. 2010 Jan 1;81(1):9-14.

ContextHypothermia improves neurological outcome for comatose survivors of out-of-hospital cardiac arrest. Use of computer controlled high surface area devices for cooling may lead to faster cooling rates and potentially improve patient outcome.ObjectiveTo compare the effectiveness of surface cooling with the standard blankets and ice packs to the Arctic Sun, a mechanical device used for temperature management.Design, Setting, And PatientsMulti-center randomized trial of hemodynamically stable comatose survivors of out-of-hospital cardiac arrest.InterventionStandard post-resuscitative care inducing hypothermia using cooling blankets and ice (n=30) or the Arctic Sun (n=34).Main Outcome MeasuresThe primary end point was the proportion of subjects who reached a target temperature within 4h of beginning cooling. The secondary end points were time interval to achieve target temperature (34 degrees C) and survival to 3 months.ResultsThe proportion of subjects cooled below the 34 degrees C target at 4h was 71% for the Arctic Sun group and 50% for the standard cooling group (p=0.12). The median time to target was 54 min faster for cooled patients in the Arctic Sun group than the standard cooling group (p<0.01). Survival rates with good neurological outcome were similar; 46% of Arctic Sun patients and 38% of standard patients had a cerebral performance category of 1 or 2 at 30 days (p=0.6).ConclusionsWhile the proportion of subjects reaching target temperature within 4h was not significantly different, the Arctic Sun cooled patients to a temperature of 34 degrees C more rapidly than standard cooling blankets.Copyright 2009 Elsevier Ireland Ltd. All rights reserved.

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