• Xiao-jin Li, Yan Kang, and Chuan Zhang.
• Intensive Care Unit, the Third People's Hospital of Chengdu, Chengdu 610031, Sichuan, China.
• Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2009 Jun 1;21(6):361-3.

ObjectiveTo investigate the correlation between subjective scoring and bispectral index (BIS) monitoring, and to study the feasibility of BIS monitor in assessing the depth of sedation for mechanically ventilated patients.MethodsA prospective randomized controlled trial was conducted. The sedation target was sedation-agitation scale (SAS) 3-4. A total of 83 patients in the intensive care unit were assigned to receive the sedation based on BIS monitor (42 cases) or the sedation based on subjective scale SAS (41 cases). The parameters of respiration, circulation, and the depth of sedation (BIS, SAS, Ramsay) were recorded. The difference between the two groups was compared. The correlation index and significance were calculated.ResultsA total of 83 patients of two groups reached the sedation target. Statistically significant difference was found between two groups in respiratory rate, fraction of inspiratory oxygen, and pulse saturation of oxygen before and after sedation (all P<0.05). After sedation, respiratory rate and fraction of inspiratory oxygen declined in all patients, while pulse saturation of oxygen rose obviously (all P<0.05). Statistically significant difference was also found in different correlation index. There was positive correlation index between BIS and SAS (r=0.626, P<0.05), a negative correlation index between BIS and Ramsay (r=-0.650, P<0.05), and also a negative correlation index between SAS and Ramsay (r=-0.908, P<0.05). Statistically significant difference was not found in the parameters of respiration and circulation between the two groups.ConclusionBIS monitor is feasible for assessing the depth of sedation in mechanically ventilated patients.

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