• Eur J Gastroenterol Hepatol · Nov 2007

    Case Reports

    Liver transplantation for nonsteroidal anti-inflammatory drug-induced liver failure: nimesulide as the first implicated compound.

    • Sergio Negrin Dastis, Jacques Rahier, Jan Lerut, and André P Geubel.
    • Department of Gastroenterology and Hepatology, St Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium.
    • Eur J Gastroenterol Hepatol. 2007 Nov 1;19(11):919-22.

    AbstractAmong industrialized countries, the rate of drug-induced liver failure varies widely accounting for about 1-12% of the indications for liver transplantation. Nonsteroidal anti-inflammatory drugs (NSAIDs) are with antibiotics the most frequently involved compounds. In this single-center series of 57 consecutive cases of acute liver failure treated by orthotopic liver transplantation, five were related to NSAIDs-induced liver damage, three being due to nimesulide use. This has to be taken as a further warning about the potential for this compound to induce liver failure.

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