• M Brignole, C Menozzi, A Moya, R Garcia-Civera, L Mont, M Alvarez, F Errazquin, J Beiras, N Bottoni, P Donateo, and International Study on Syncope of Uncertain Etiology (ISSUE) Investigators.
• Departments of Cardiology, Ospedali Riuniti, Lavagna, Italy. mbrignole@ASL4.liguria.it
• Circulation. 2001 Oct 23;104(17):2045-50.

BackgroundIn patients with syncope and bundle branch block (BBB), syncope is suspected to be attributable to a paroxysmal atrioventricular (AV) block, but little is known of its mechanism when electrophysiological study is negative.Methods And ResultsWe applied an implantable loop recorder in 52 patients with BBB and negative conventional workup. During a follow-up of 3 to 15 months, syncope recurred in 22 patients (42%), the event being documented in 19 patients after a median of 48 days. The most frequent finding, recorded in 17 patients, was one or more prolonged asystolic pause mainly attributable to AV block; the remaining 2 patients had normal sinus rhythm or sinus tachycardia. The onset of the bradycardic episodes was always sudden but was sometimes preceded by ventricular premature beats. The median duration of the arrhythmic event was 47 seconds. An additional 3 patients developed nonsyncopal persistent III-degree AV block, and 2 patients had presyncope attributable to AV block with asystole. No patients suffered injury attributable to syncopal relapse.ConclusionsIn patients with BBB and negative electrophysiological study, most syncopal recurrences have a homogeneous mechanism that is characterized by prolonged asystolic pauses, mainly attributable to sudden-onset paroxysmal AV block.

28 keywords...

hide…