• Vox sanguinis · Jan 2011

    Review

    Antibody-mediated (immune) transfusion-related acute lung injury.

    • J Bux.
    • German Red Cross Blood Service West, Hagen, Germany. j.bux@bsdwest.de
    • Vox Sang. 2011 Jan 1;100(1):122-8.

    AbstractAntibody-mediated transfusion-related acute lung injury (immune TRALI) is now recognized as the most common cause of transfusion-associated major morbidity and death in the Western world. Among the implicated leucocyte antibodies, these ones directed against the human leucocyte antigens (HLA) class II, human neutrophil alloantigens (HNA)-3a and HLA-A2 antigens are frequently associated with severe (artificial ventilation required) and fatal cases. There is accumulating evidence that preventive measures such as transfusion of plasma-rich blood components from male donors or from donors tested negative for leucocyte antibodies are effective in the reduction of severe and fatal immune TRALI.© 2010 The Author(s). Vox Sanguinis © 2010 International Society of Blood Transfusion.

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