• Intensive care medicine · Nov 2008

    Multicenter Study

    Impact of obesity in mechanically ventilated patients: a prospective study.

    • Jean-Pierre Frat, Valérie Gissot, Stéphanie Ragot, Arnaud Desachy, Isabelle Runge, Christine Lebert, René Robert, and Association des Réanimateurs du Centre-Ouest (ARCO) study group.
    • Medical ICU, CHU Poitiers, Poitiers, France. j.p.frat@chu-poitiers.fr
    • Intensive Care Med. 2008 Nov 1;34(11):1991-8.

    ObjectiveTo analyze the influence of severe obesity on mortality and morbidity in mechanically ventilated intensive care unit (ICU) patients.DesignProspective, multi-center exposed/unexposed matched epidemiologic study.SettingHospital setting.PatientsSeverely obese patients (body mass index (BMI) >or= 35 kg/m(2)), mechanically ventilated for at least 2 days were matched with unexposed nonobese patients (BMI < 30 kg/m(2)) for center, gender, age (+/-5 years), and the simplified acute physiology (SAPS) II score (+/-5 points). We recorded tracheal intubation, catheter placement, nosocomial infections, development of pressure ulcers, ICU and hospital outcome.ResultsEighty-two severely obese patients (mean BMI, 42 +/- 6 kg/m(2)) were compared to 124 nonobese patients (mean BMI, 24 +/- 4 kg/m(2)). The ICU course was similar in both the groups, except for the difficulties during tracheal intubation (15 vs. 6%) and post-extubation stridor (15% vs. 3%), which were significantly more frequent in obese patients (P < 0.05). The ICU mortality rate did not differ between obese and nonobese patients (24 and 25%, respectively); nor did the risk-adjusted hospital mortality rate (0.76, 95% confidence interval 0.41-1.16 in obese patients versus 0.82, 95% confidence interval 0.54-1.13 in nonobese patients). Conditional logistic regression confirmed that mortality was not associated with obesity.ConclusionThe only difference in morbidity of obese patients who were mechanically ventilated was increased difficulty with tracheal intubation and a higher frequency of post-extubation stridor. Obesity was not associated either with increased ICU mortality or with hospital mortality.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…

What will the 'Medical Journal of You' look like?

Start your free 21 day trial now.

We guarantee your privacy. Your email address will not be shared.