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Acta Anaesthesiol. Sin. · Jun 2000
Case ReportsFatal anaphylactoid shock associated with protamine for heparin reversal during anesthesia.
- C H Peng, P H Tan, C H Lin, H Y Lin, C H Kuo, and H C Chung.
- Department of Anesthesiology, Feng Yuan Hospital, Taiwan, R.O.C. Peng@mail.fyh.tpg.gov.tw
- Acta Anaesthesiol. Sin. 2000 Jun 1;38(2):97-102.
AbstractA 19-year-old female was scheduled for elective surgery of repair of ventricular septal defect (VSD). She had no known previous food or drug allergy history. She was not previously exposed to protamine and did not have any of the risk factors pointing to protamine hypersensitivity reaction. Unfortunately there were two anaphylactoid shocks occurring during this surgery. One was caused by intravenous (i.v.) administration of antibiotics, and the other happened following i.v. drip of protamine sulfate for reversal of systemic heparinization. She had none of the risk factors suggestive of hypersensitivity to drugs and was therefore considered not at risk for such severe adverse reactions which happened. This article was to discuss the anaphylactoid shock induced by antibiotics and protamine during anesthesia, and the prevention and management of such a reaction.
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