• Neurosurgery · Dec 2009

    Case Reports

    Preoperative sensorimotor mapping in brain tumor patients using spontaneous fluctuations in neuronal activity imaged with functional magnetic resonance imaging: initial experience.

    • Dongyang Zhang, James M Johnston, Michael D Fox, Eric C Leuthardt, Robert L Grubb, Michael R Chicoine, Matthew D Smyth, Abraham Z Snyder, Marcus E Raichle, and Joshua S Shimony.
    • Department of Radiology, Washington University in St. Louis, St. Louis, Missouri 63110, USA. zhangd@npg.wustl.edu
    • Neurosurgery. 2009 Dec 1;65(6 Suppl):226-36.

    ObjectiveTo describe initial experience with resting-state correlation mapping as a potential aid for presurgical planning of brain tumor resection.MethodsResting-state blood oxygenation-dependent functional magnetic resonance imaging (fMRI) scans were acquired in 17 healthy young adults and 4 patients with brain tumors invading sensorimotor cortex. Conventional fMRI motor mapping (finger-tapping protocol) was also performed in the patients. Intraoperatively, motor hand area was mapped using cortical stimulation.ResultsRobust and consistent delineation of sensorimotor cortex was obtained using the resting-state blood oxygenation-dependent data. Resting-state functional mapping localized sensorimotor areas consistent with cortical stimulation mapping and in all patients performed as well as or better than task-based fMRI.ConclusionResting-state correlation mapping is a promising tool for reliable functional localization of eloquent cortex. This method compares well with "gold standard" cortical stimulation mapping and offers several advantages compared with conventional motor mapping fMRI.

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