• Clinics in liver disease · Feb 2009

    Review

    Coagulopathy of acute liver failure.

    • Santiago J Munoz, R Todd Stravitz, and Don A Gabriel.
    • University of Pennsylvania, School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA. Santiago.Munoz@uphs.upenn.edu
    • Clin Liver Dis. 2009 Feb 1;13(1):95-107.

    AbstractCoagulopathy is an essential component of the acute liver failure (ALF) syndrome and reflects the central role of liver function in hemostasis. ALF is a syndrome characterized by the development of hepatic encephalopathy and coagulopathy within 24 weeks of the onset of acute liver disease. Coagulopathy in this setting is a useful prognostic tool in ALF and a dynamic indicator of the hepatic function. If severe, it can be associated with bleeding and is commonly a major obstacle to the performance of invasive procedures in patients with ALF. This review focuses on the epidemiology, pathophysiology, presentation, evaluation, and management of coagulopathy in ALF.

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