• Masahiko Onaka and Hiromitsu Yamamoto.
• Department of Anesthesia, Shiroyama Hospital, Habikino 583-0852.
• Masui. 2006 Feb 1;55(2):174-8.

BackgroundThe clinical effect of continuous infusion of landiolol with buprenorphine and lidocaine was evaluated for its effects an attenuating the cardiovascular responses to endotracheal intubation.MethodsTracheal intubation was performed by the same anesthesiologist after induction of anesthesia with propofol, ketamine, midazolam, buprenorphine and lidocaine, followed by administration of vecuronium, and continuous infusion of saline (Group C; n = 20) or landiolol 0.02 (Group L 2; n = 25) or landiolol 0.04 mg x kg(-1) x min(-1) (Group L4; n = 22). Heart rate (HR), systolic (sBP) and diastolic blood pressure (dBP) were recorded just before induction of anesthesia, just after and 10 min after tracheal intubation.ResultsJust after tracheal intubation, HR in the Groups C and L 2, but not in the group L 4, increased significantly from the baseline. Just after the tracheal intubation, sBP in the Group L 2 decreased from the baseline, and 10 min after intubation sBP in all groups decreased significantly from the baseline. Just after tracheal intubation, dBP in all groups was unchanged, and dBP in the Groups C and L 4 decreased from the baseline 10 min after the intubation.ConclusionsContinuous infusion of landiolol 0.04 mg x kg(-1) x h(-1) with buprenorphine and lidocaine can completely attenuate the hemodynamic response to tracheal intubation.

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