• Br J Anaesth · Mar 2001

    Suppressive effect of nitrous oxide on motor evoked potentials can be reversed by train stimulation in rabbits under ketamine/fentanyl anaesthesia, but not with additional propofol.

    • T Sakamoto, M Kawaguchi, S Inoue, and H Furuya.
    • Department of Anesthesiology, Nara Medical University, Kashihara, Japan.
    • Br J Anaesth. 2001 Mar 1;86(3):395-402.

    AbstractThe effect of nitrous oxide on myogenic motor evoked potentials (MEPs) after multipulse stimulation is controversial. We investigated the effects of propofol in this paradigm. MEPs were elicited electrically by a single pulse and by trains of three and five pulses in rabbits anaesthetized with ketamine and fentanyl. Nitrous oxide 30-70% was given and MEPs were recorded. After washout of nitrous oxide, propofol was given as a bolus of 10 mg kg(-1) followed by 0.8 (n=9) or 1.6 mg kg(-1) min(-1) (n=8) as a continuous infusion. Nitrous oxide was then re-administered and MEPs were recorded. Without propofol, nitrous oxide significantly reduced the amplitude of MEPs dose-dependently, but this effect was reversed by multipulse stimulation. Administration of low-dose propofol enhanced nitrous oxide-induced suppression, and this effect was reversed by five-pulse stimulation. However, high-dose propofol produced a greater increase in suppression, such that even five-pulse stimulation did not overcome the suppression. The results suggest that the degree of reversal of nitrous oxide-induced MEP suppression produced by multipulse stimulation is affected by the administration of propofol.

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