• Rev Esp Med Nucl Imagen Mol · Mar 2014

    Case Reports

    Bone scintigraphy and secondary osteomalacia due to nephrotoxicity in a chronic hepatitis B patient treated with tenofovir.

    • M V Gómez Martinez, F G Gallardo, T Pirogova, and J García-Samaniego.
    • Servicio de Medicina Nuclear y Unidad de Hepatología, Hospital Carlos III, Centro de Investigación Biomédica en Red de Enfermedades y Digestivas (CIBERehd), Madrid, Spain. Electronic address: marivalgomez@gmail.com.
    • Rev Esp Med Nucl Imagen Mol. 2014 Mar 1;33(2):103-5.

    AbstractTenofovir is a nucleotide analogue used for the treatment of chronic hepatitis B and HIV infection. The safety of tenofovir is high but it has been described that tenofovir produces tubular toxicity and Fanconi's syndrome in some HIV-infected patients. To our knowledge this is the first documented case of bone involvement in Fanconi's syndrome in a patient treated with tenofovir for chronic hepatitis B without HIV coinfection. Bone scintigraphy has proven to be very useful for the diagnosis of secondary osteomalacia. Normalization of the bone scan after the withdrawal of the drug and the decline in alkaline phosphatase and phosphate serum levels reinforce the cause-effect relationship.Copyright © 2013 Elsevier España, S.L. and SEMNIM. All rights reserved.

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