• J G Meechan, B Cole, and R R Welbury.
• Department of Oral and Maxillofacial Surgery, The Dental School, University of Newcastle Upon Tyne. J.G.Meechan@ncl.ac.uk
• Br Dent J. 2001 May 12;190(9):502-4.

ObjectivesThis investigation was designed to study the haemodynamic effects of two different local anaesthetic solutions during restorative dental treatment in children.DesignA randomised, single-blind, split-mouth cross-over design was employed using children undergoing bilaterally similar restorative treatments over two visits.SettingThe study was performed in a dental hospital paediatric dentistry department.MethodsTen children participated. At one visit the local anaesthetic was 2% lidocaine (lignocaine) with 1:80,000 epinephrine (adrenaline); at the other the anaesthetic was 3% prilocaine with 0.03IU/ml felypressin. Local anaesthetic was administered at a dose of 0.5 ml/10 kg body weight. Blood pressure and heart rate were measured before and during treatment with an automatic blood pressure recorder. Data were analysed by ANOVA and Student's paired t test.ResultsSignificant differences between treatments in diastolic blood pressure (F = 2.37; P = 0.05) and heart rate (F = 2.98; P< 0.02) were noted. The heart rate increased ten minutes following the injection of the epinephrine-containing solution. The diastolic blood pressure fell 20 minutes after injection of lidocaine with epinephrine.ConclusionThe choice of local anaesthetic solution influences the haemodynamic response during restorative treatment in children.

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