• Biology of the neonate · Jan 1995

    Case Reports

    Intrathecal immune response in neonatal Flavobacterium meningosepticum meningitis.

    • T G Abrahamsen, T E Mollnes, and B Vandvik.
    • Department of Pediatrics, Rikshospitalet, Oslo, Norway.
    • Biol. Neonate. 1995 Jan 1;68(2):153-6.

    AbstractNeonates are predisposed to serious infections such as meningitis, probably due to their immature host reaction to the pathogens. We have studied the intrathecal immune response in 2 newborns with Flavobacterium meningosepticum meningitis. They showed a significant elevation of immunoglobulin indices ( >1.10), also after the CSF had become sterile with a normalized cell count. In addition, an intrathecal increase and subsequent decrease of both C3dg and TCC (terminal complement complex) were observed in 1 patient. We conclude that immunoglobulin production and complement activation may occur in neonatal CSF.

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