• Laszlo M Hoesel, Hongwei Gao, and Peter A Ward.
• Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
• Immunol. Res. 2006 Jan 1;34(2):133-41.

AbstractDespite intensive ongoing research efforts, the mortality of patients with sepsis remains unacceptably high. Clinical trials emerging from promising results in animal models have mostly failed to deliver sufficient treatment strategies so far. Many studies investigating the underlying mechanisms of sepsis have focused on deterioration of the humoral and cellular components of the immune system. However, in addition to septic shock, the main cause of death in septic patients is multiorgan failure. So far, not much is known about the effects of a dysregulated immune system as seen in sepsis on parenchymal cells of end organs. Studies on the interaction of the complement system and kidney as well as liver cells resulted in interesting yet still inconclusive data. In this review, we provide new insights into mechanisms during sepsis based on recent findings.

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