• Ann. N. Y. Acad. Sci. · Aug 2012

    Review

    Moving toward a generalizable application of central thalamic deep brain stimulation for support of forebrain arousal regulation in the severely injured brain.

    • Nicholas D Schiff.
    • Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, USA. nds2001@med.cornell.edu
    • Ann. N. Y. Acad. Sci. 2012 Aug 1;1265:56-68.

    AbstractThis review considers the challenges ahead for developing a generalizable strategy for the use of central thalamic deep brain stimulation (CT/DBS) to support arousal regulation mechanisms in the severely injured brain. Historical efforts to apply CT/DBS to patients with severe brain injuries and a proof-of-concept result from a single-subject study are discussed. Circuit and cellular mechanisms underlying the recovery of consciousness are considered for their relevance to the application of CT/DBS, to improve consciousness and cognition in nonprogressive brain injuries. Finally, directions for development, and testing of generalizable criteria for CT/DBS are suggested, which aim to identify neuronal substrates and behavioral profiles that may optimally benefit from support of arousal regulation mechanisms.© 2012 New York Academy of Sciences.

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