• G Umberto Meduri, Emmel Golden, Amado X Freire, Edwin Taylor, Muhammad Zaman, Stephanie J Carson, Mary Gibson, and Reba Umberger.
• Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center, 956 Court Ave, Room H316, Memphis, TN 38163, USA. umeduri@utmem.edu
• Chest. 2007 Apr 1;131(4):954-63.

ObjectiveTo determine the effects of low-dose prolonged methylprednisolone infusion on lung function in patients with early severe ARDS.DesignRandomized, double-blind, placebo-controlled trial.SettingICUs of five hospitals in Memphis.ParticipantsNinety-one patients with severe early ARDS (InterventionsPatients were randomized (2:1 fashion) to methylprednisolone infusion (1 mg/kg/d) vs placebo. The duration of treatment was up to 28 days. Infection surveillance and avoidance of paralysis were integral components of the protocol.Main Outcome MeasureThe predefined primary end point was a 1-point reduction in lung injury score (LIS) or successful extubation by day 7.ResultsIn intention-to-treat analysis, the response of the two groups (63 treated and 28 control) clearly diverged by day 7, with twice the proportion of treated patients achieving a 1-point reduction in LIS (69.8% vs 35.7%; p = 0.002) and breathing without assistance (53.9% vs 25.0%; p = 0.01). Treated patients had significant reduction in C-reactive protein levels, and by day 7 had lower LIS and multiple organ dysfunction syndrome scores. Treatment was associated with a reduction in the duration of mechanical ventilation (p = 0.002), ICU stay (p = 0.007), and ICU mortality (20.6% vs 42.9%; p = 0.03). Treated patients had a lower rate of infections (p = 0.0002), and infection surveillance identified 56% of nosocomial infections in patients without fever.ConclusionsMethylprednisolone-induced down-regulation of systemic inflammation was associated with significant improvement in pulmonary and extrapulmonary organ dysfunction and reduction in duration of mechanical ventilation and ICU length of stay.

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