• Front Mol Neurosci · Jan 2015

    Review

    The role of the ubiquitin-editing enzyme A20 in diseases of the central nervous system and other pathological processes.

    • Asghar Abbasi, Kirsi Forsberg, and Felix Bischof.
    • Department of Neuroimmunology, Hertie Institute for Clinical Brain Research and Center of Neurology, University Hospital Tübingen Tübingen, Germany.
    • Front Mol Neurosci. 2015 Jan 1;8:21.

    AbstractIn recent years, the ubiquitin-editing enzyme A20 has been shown to control a large set of molecular pathways involved in the regulation of protective as well as self-directed immune responses. Here, we assess the current and putative roles of A20 in inflammatory, vascular and degenerative diseases of the central nervous system and explore future directions of research.

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