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Prog Cardiovasc Dis · Jul 2000
ReviewLeft ventricular assist device-induced reverse ventricular remodeling.
- D Burkhoff, J W Holmes, J Madigan, A Barbone, and M C Oz.
- Department of Medicine, Columbia University, New York, NY 10032, USA. db59@columbia.edu
- Prog Cardiovasc Dis. 2000 Jul 1;43(1):19-26.
AbstractLeft ventricular assist devices provide chronic pressure and volume unloading of the dilated left ventricle in patients with end-stage heart failure. This is associated with reverse structural remodeling (normalization of the passive pressure-volume relationship), reverse molecular remodeling (increased expression of several genes involved in calcium metabolism that are down-regulated in heart failure), improved baseline contractility, and improved contractile response to increased heart rate and to beta-agonist stimulation. These findings indicate the profound degree of recovery of myocardial properties in hearts previously considered to have invincible end-stage heart failure.
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