• Christina M Holmes and Mitchell J Goldman.
• Department of Pediatrics, Peyton Manning Children's Hospital, Indianapolis, Indiana 46240, USA.
• J Emerg Med. 2012 Dec 1;43(6):e447-9.

BackgroundGelastic seizures are defined as seizure activity manifesting as laughter inappropriate to the situation, with supporting evidence on electroencephalogram or magnetic resonance imaging. Gelastic seizures are most commonly reported in patients with hypothalamic hamartomas causing precocious puberty. The differential diagnosis of incessant laughter is important to recognize in the Emergency Department, as some conditions warrant immediate treatment and others require further diagnostic work-up with implications for the entire family.ObjectivesThe background and pathophysiology of gelastic epilepsy will be discussed.Case ReportThe case of a previously healthy girl with acute onset of incessant laughter is reported. This patient was diagnosed with a clinical case of gelastic seizures. This case illustrates the importance of recognizing this form of seizures for accurate treatment and follow-up.ConclusionThis case report illustrates the importance of a broad differential for a patient presenting emergently with uncontrollable laughter. Gelastic epilepsy is relatively rare but requires further work-up and often may require chronic therapy.Copyright © 2012 Elsevier Inc. All rights reserved.

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