• Pediatrics · Jul 2013

    Case Reports

    Trisomy 18 and complex congenital heart disease: seeking the threshold benefit.

    • Renee D Boss, Kathryn W Holmes, Janyne Althaus, Cynda H Rushton, Hunter McNee, and Theresa McNee.
    • Department of Pediatrics, Johns Hopkins University School of Medicine, Johns Hopkins University School of Nursing, Baltimore, MD, USA. rboss1@jhmi.edu
    • Pediatrics. 2013 Jul 1;132(1):161-5.

    AbstractA prenatal diagnosis of ductal-dependent, complex congenital heart disease was made in a fetus with trisomy 18. The parents requested that the genetic diagnosis be excluded from all medical and surgical decision-making and that all life-prolonging therapies be made available to their infant. There was conflict among the medical team about what threshold of neonatal benefit could outweigh maternal and neonatal treatment burdens. A prenatal ethics consultation was requested.

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