• O Leroy, C Bosquet, C Vandenbussche, C Coffinier, H Georges, B Guery, S Alfandari, D Thevenin, and G Beaucaire.
• Service de Réanimation Médicale et Maladies Infectieuses, CHRU Lille, Centre Hospitalier, Tourcoing, France.
• J Am Geriatr Soc. 1999 May 1;47(5):539-46.

ObjectivesTo compare epidemiological data, etiology, and prognosis of severe community-acquired pneumonia (CAP) in the intensive care unit (ICU) according to age (< or > or = 65 years) and to determine prognostic factors of CAP in older people.DesignA retrospective (1987-1992) and prospective (1993-95) multicenter study.SettingSix ICUs in the north of France.PatientsFive hundred five patients admitted to an ICU for severe CAP.MeasurementsPatient characteristics were compared with regard to age. Prognosis of CAP in older patients was studied by stepwise discriminant analysis.ResultsTwo hundred seventy-eight patients (55%) were aged 65 years or older. Comparison of epidemiological data between older and younger patients revealed a higher prevalence of women (38% vs 29%), more severe underlying comorbidities (anticipated death within 5 years: 59% vs 26%), and more frequent chronic respiratory insufficiency (48% vs 33%) in the older patients. In this study group, 224 organisms were isolated from 172 patients (62%); those identified most frequently were Gram-negative bacilli (34%), S. pneumoniae (32%), and Staphylococcus sp. (19%). Compared with younger patients, no significant differences in bacteriological data were observed. However, crude and attributable mortality rates were significantly higher in the older patients (33% vs 21% and 30% vs 19%, respectively). Prognosis analysis identified four independent predictors of mortality in the older patients: initial septic shock (relative risk (RR) = 3), sepsis-related complications (RR = 4.3), hospital-acquired lower respiratory tract superinfections (RR = 2), and nonspecific pneumonia-related complications (RR = 2.8).ConclusionThe bacterial etiology provides some approaches to empirical therapy for older patients with severe community-acquired pneumonia. In addition, the inappropriateness of withholding intensive care for reasons of age alone is emphasized.

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