• Kwon-Hui Seo, Yong-Il Kim, and Yong-Shin Kim.
• Department of Anesthesiology and Pain Medicine, St Vincent Hospital, Catholic University of Korea, Suwon, Republic of Korea.
• J. Int. Med. Res. 2014 Oct 1;42(5):1139-49.

ObjectiveTo investigate the optimal dose of dexmedetomidine for attenuating the haemodynamic response during emergence from anaesthesia.MethodsPatients undergoing laparoscopic total hysterectomy were randomly allocated to receive 0.9% normal saline (control group) or dexmedetomidine (0.5 µg/kg, 0.75 µg/kg or 1.0 µg/kg 30 min) before extubation. Heart rate, systolic and diastolic arterial pressure and extubation time were measured before drug administration, immediately after the end of drug administration, 10 min after the end of drug administration, immediately after extubation and 5 min after extubation.ResultsA total of 120 patients were included in the study (30 per group). Systolic and diastolic arterial pressure and heart rate after drug administration were significantly lower in all three dexmedetomidine groups compared with controls. Extubation times in the 0.75 and 1.0 µg/kg dexmedetomidine groups were significantly longer than in the control group.ConclusionIntravenous infusion of 0.5 µg/kg dexmedetomidine 30 min before the end of surgery attenuated the haemodynamic responses during emergence without prolonging the extubation time. Dexmedetomidine doses higher than 0.5 µg/kg did not exert additional positive effects on cardiovascular responses, but did significantly prolong the extubation time.© The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

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