• J. Neuroimmunol. · Aug 2015

    Central and systemic inflammatory responses to thoracotomy - potential implications for acute and chronic postsurgical pain.

    • Richard M Talbot, Kevin F McCarthy, and Connail McCrory.
    • Department of Pain Medicine, St. James's Hospital, Dublin, Ireland.
    • J. Neuroimmunol. 2015 Aug 15;285:147-9.

    AbstractChronic postsurgical pain (CPSP) may affect up to 70% of patients after surgery. Glial and immune mediators have been implicated in the pathogenesis of chronic postsurgical pain. Our objective was to study cerebrospinal fluid (CSF) and serum concentrations of IL-1β, IL-6, IL-8, IL-10, IFNγ and TNFα over a 72-hour period in patients undergoing a thoracotomy and oesophagectomy. Despite adequate pain control, thoracotomy was still associated with significant central and peripheral inflammation. This must be taken into consideration in planning future strategies to prevent CPSP.Copyright © 2015 Elsevier B.V. All rights reserved.

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