• Science · Oct 2009

    Randomized Controlled Trial

    Direct evidence for spinal cord involvement in placebo analgesia.

    • Falk Eippert, Jürgen Finsterbusch, Ulrike Bingel, and Christian Büchel.
    • Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. f.eippert@uke.uni-hamburg.de
    • Science. 2009 Oct 16;326(5951):404.

    AbstractPlacebo analgesia is a prime example of the impact that psychological factors have on pain perception. We used functional magnetic resonance imaging of the human spinal cord to test the hypothesis that placebo analgesia results in a reduction of nociceptive processing in the spinal cord. In line with behavioral data that show decreased pain responses under placebo, pain-related activity in the spinal cord is strongly reduced under placebo. These results provide direct evidence for spinal inhibition as one mechanism of placebo analgesia and highlight that psychological factors can act on the earliest stages of pain processing in the central nervous system.

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