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- T Murakami, T Shibata, Y Sasaki, M Hosono, S Suehiro, and H Kinoshita.
- Division of Cardiovascular Surgery, Osaka City University Medical School, Abeno, Osaka, Japan.
- J Heart Valve Dis. 2001 May 1;10(3):377-9.
AbstractCongenital factor XII deficiency is a rare condition. We report a case of aortic valve replacement (AVR) in a 63-year-old man with factor XII deficiency. On admission, the patient's activated partial thromboplastin time (aPTT) was prolonged (271 s), and activated clotting time was 500 s. His factor XII level was <3%. The Sonoclot signature showed an abnormal pattern. AVR with a prosthetic valve (St. Jude Medical) was performed safely after the normalization of aPTT and the Sonoclot signature by frozen plasma transfusion. The perioperative management in patients with factor XII deficiency is discussed.
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